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KMID : 0363320060270010092
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 1 p.92 ~ p.101
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The Effect of Daecheongryong-tang and prescription A on airway mucin secretion
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Park Wan-Yeol
Suh Woon-Gyo
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Abstract
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Objectives : This study was done with intend to investigate whether two oriental medical prescriptions, daecheongryong-tang (DCRT) and prescription A (P-A) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells.
Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of DCRT or P-A to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of DCRT and P-A on contractility of isolated tracheal smooth muscle were investigated.
Results were as follows :
1. DCRT significantly inhibited mucin release from cultured HTSE cells, with significant cytotoxicity.
2. P-A significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity.
3. DCRT inhibited Ach-induced contraction of isolated tracheal smooth muscle.
4. P-A also inhibited Ach-induced contraction of isolated tracheal smooth muscle.
Conclusion: Results suggest that DCRT and P-A have regulating effects on mucin secretion from goblet cells. Further investigation is needed, because of the value in finding novel agents to this purpose, and these oriental medical prescriptions have potential for this role.
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KEYWORD
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airway, mucus, mucin, daecheongryong-tang (DCRT) and prescription A (P-A)
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